منابع مشابه
Effects of age, antigen deprivation, and allograft rejection on epithelial cell kinetics in mouse colon.
A technique of microdissection of colonic mucosa has allowed the study of mitotic activity, measured by metaphase accumulation following colchicine blockade, in individual crypts of mouse colon. The changes occurring during growth and development of normal colon have been studied and compared with changes found in antigen free colon (colonic isografts) and in cell-mediated immune damage of the ...
متن کاملColorectal epithelial cell proliferative kinetics and risk factors for colon cancer in sporadic adenoma patients.
Colorectal epithelial cell proliferative kinetics are altered in patients at increased risk for colon cancer: proliferation rates [labeling index (LI)] are higher and there is a shift of the proliferative zone from one confined to the lower 60% of the colonic crypt to one that includes the entire crypt (higher phi(h)). To assess factors associated with LI and phi(h), we performed a cross-sectio...
متن کاملCell Surface Glycopeptides from Human Intestinal Epithelial Cell Lines Derived from Normal Colon and Colon Adenocarcinomas1
The cell surface glycopeptides from an epithelial cell line (CCL 239) derived from normal human colon were compared with those from three cell lines (HCT-8R, HCT-15, and CaCo-2) derived independently from human colonie adenocarcinomas. Cells were incubated with o-[2-3H]mannose or L-[5,6-3H]fucose for 24 h and treated with trypsin to release cell surface compo nents which were then digested exha...
متن کاملCell surface glycopeptides from human intestinal epithelial cell lines derived from normal colon and colon adenocarcinomas.
The cell surface glycopeptides from an epithelial cell line (CCL 239) derived from normal human colon were compared with those from three cell lines (HCT-8R, HCT-15, and CaCo-2) derived independently from human colonic adenocarcinomas. Cells were incubated with D-[2-3H]mannose or L-[5,6-3H]fucose for 24 h and treated with trypsin to release cell surface components which were then digested exhau...
متن کاملMurine Colon Epithelial Cell Proliferation and Neoplasia Muscarinic Receptors Attenuates
Colon epithelial cells express and most colon cancers overexpress M3 muscarinic receptors (M3R). In human colon cancer cells, post-M3R signaling stimulates proliferation. To explore the importance of M3R expression in vivo , we used the azoxymethane-induced colon neoplasia model. Mice treated with weekly i.p. injection of saline [10 wild-type (WT) mice] or azoxymethane (22 WT and 16 M3R / mice)...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Gastroenterology
سال: 1984
ISSN: 0016-5085
DOI: 10.1016/0016-5085(84)90176-8